Backed by Y Combinator
Foundation models for RNA therapeutics
Our Research
Work that shaped our foundation. Developed by the Blank Bio team during their time at the
University of Toronto, Vector Institute, and MSK.
Orthrus
Our first, lightweight model trained contrastively on splice-isoform and ortholog pairs for mRNA sequence optimization.
Orthrus+MLM
An enhanced Orthrus that layers in language-style learning for SOTA performance on mRNA property prediction tasks.
mRNA Bench
An open benchmark of 10 curated datasets and 59 prediction tasks that probe mature-mRNA biology—half-life, ribosome load, localisation, RBP binding and more—under rigorous, biologically aware data splits.